BL/CH401 Lecture 10
Evolution of Protein Structures
Part IV. Summary of Lecture 10

Part IV. Summary of Lecture 10

3 Classes of Proteins/Enzymes were identified in this lecture:

I. Homologous -- Same 3-D shape, AA sequence, Function

Same 3-D shape
Highly Similar AA sequence
Same Function
example = Cytochrome c

II. Similar function - different sequence

One domain same shape
One domain different
example Dehydrogenases

III. Similar Shape - Different Function and Different Sequence

Same 3-D shape
Not same function
example b-barrels

Most General Conclusion:

Protein 3-D shape more conserved during evolution than the amino acid sequence